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- Title
SYNTHESIS INDUCED BY MICROWAVE IRRADIATIO AND IN VITRO ANTIFUNGAL EVALUATION OF NEW DIHYDROPYRAZOLO[3,4-b] [1,4]DIAZEPINES.
- Authors
Insuasty, Braulio; Quiroga, Jairo; Abonia, Rodrigo; Insuasty, Henry; Mosquera, Monica; Cruz, Silvia; Nogueras, Manuel; Sortino, Maximiliano; Zacchino, Susana
- Abstract
New 2- and 4-methylenedioxyphenyl-8-phenyl-2,3-dihydropyrazolo[3,4-b]diazepines 3 were obtained from the reaction of 4,5-diamino-3-methyl-l-phenylpyrazole 1 with one equivalent of the methylenedioxychalcones 2 in both absolute ethanol and under solvent-free conditions microwave irradiation. The structures of diazepines 3 were determined by detailed nmr measurements. These compounds does not showed any antifungal in vitro activity up to 250 μg/ml.
- Publication
Heterocyclic Communications, 2004, Vol 10, Issue 1, p103
- ISSN
0793-0283
- Publication type
Article