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- Title
The Mechanical Microenvironment in Breast Cancer.
- Authors
Pratt, Stephen J.P.; Lee, Rachel M.; Martin, Stuart S.
- Abstract
Mechanotransduction is the interpretation of physical cues by cells through mechanosensation mechanisms that elegantly translate mechanical stimuli into biochemical signaling pathways. While mechanical stress and their resulting cellular responses occur in normal physiologic contexts, there are a variety of cancer-associated physical cues present in the tumor microenvironment that are pathological in breast cancer. Mechanistic in vitro data and in vivo evidence currently support three mechanical stressors as mechanical modifiers in breast cancer that will be the focus of this review: stiffness, interstitial fluid pressure, and solid stress. Increases in stiffness, interstitial fluid pressure, and solid stress are thought to promote malignant phenotypes in normal breast epithelial cells, as well as exacerbate malignant phenotypes in breast cancer cells.
- Subjects
BREAST tumor risk factors; BIOPHYSICS; BREAST; CELL physiology; CELLULAR signal transduction; EPITHELIAL cells; EXTRACELLULAR fluid; RISK assessment; PHENOTYPES; PHYSIOLOGIC strain
- Publication
Cancers, 2020, Vol 12, Issue 6, p1452
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers12061452