We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Epstein-Barr Virus in Gastric Carcinoma.
- Authors
Jun Nishikawa; Hironori Yoshiyama; Hisashi Iizasa; Yuichi Kanehiro; Munetaka Nakamura; Junichi Nishimura; Mari Saito; Takeshi Okamoto; Kouhei Sakai; Yutaka Suehiro; Takahiro Yamasaki; Atsunori Oga; Hideo Yanai; Isao Sakaida
- Abstract
The Epstein-Barr virus (EBV) is detected in about 10% of gastric carcinoma cases throughout the world. In EBV-associated gastric carcinoma, all tumor cells harbor the clonal EBV genome. Gastric carcinoma associated with EBV has distinct clinicopathological features, occurs predominately in men and in younger-aged individuals, and presents a generally diffuse histological type. Most cases of EBV-associated gastric carcinoma exhibit a histology rich in lymphocyte infiltration. The immunological reactiveness in the host may represent a relatively preferable prognosis in EBV-positive cases. This fact highlights the important role of EBV in the development of EBV-associated gastric carcinoma. We have clearly proved direct infection of human gastric epithelialcells by EBV. The infection was achieved by using a recombinant EBV. Promotion of growth by EBV infection was observed in the cells. Considerable data suggest that EBV may directly contribute to the development of EBV-associated GC. This tumor-promoting effect seems to involve multiple mechanisms, because EBV affects several host proteins and pathways that normally promote apoptosis and regulate cell proliferation.
- Subjects
ASIA; EPSTEIN-Barr virus diseases; STOMACH tumors; DNA methylation; PROGNOSIS; TUMOR treatment
- Publication
Cancers, 2014, Vol 6, Issue 4, p2259
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers6042259