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- Title
Using Genetically Encoded Calcium Indicators to Study Astrocyte Physiology: A Field Guide.
- Authors
Lohr, Christian; Beiersdorfer, Antonia; Fischer, Timo; Hirnet, Daniela; Rotermund, Natalie; Sauer, Jessica; Schulz, Kristina; Gee, Christine E.
- Abstract
Ca2+ imaging is the most frequently used technique to study glial cell physiology. While chemical Ca2+ indicators served to visualize and measure changes in glial cell cytosolic Ca2+ concentration for several decades, genetically encoded Ca2+ indicators (GECIs) have become state of the art in recent years. Great improvements have been made since the development of the first GECI and a large number of GECIs with different physical properties exist, rendering it difficult to select the optimal Ca2+ indicator. This review discusses some of the most frequently used GECIs and their suitability for glial cell research.
- Subjects
CALCIUM; CELL physiology; NEUROGLIA; PHYSIOLOGY; INDICATORS &; test-papers
- Publication
Frontiers in Cellular Neuroscience, 2021, Vol 15, p1
- ISSN
1662-5102
- Publication type
Article
- DOI
10.3389/fncel.2021.690147