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- Title
Fabrication of folic acid–cysteamine-modified silver nanoparticles as promising contrast agent for computed tomography imaging.
- Authors
Lian, Wei; Gan, Min
- Abstract
The present work demonstrates the biosynthesis of silver nanoparticles (AgNPs) using Coffea arabica leaf extract. The AgNPs prepared by green route from C. arabica leaf were characterized through UV–visible, X-ray diffraction, transmission electron microscopy and energy-dispersive electron spectroscopy. Later, the prepared NPs were conjugated with cysteamine–folic acid and utilized as a contrast medium for in vitro targeted imaging of folic acid receptor-expressing malignant cells by computerized tomography (CT). At 80 kVp, the targeted cells exhibited CT values which were two times greater than that of the non-targeted cells. The results were compared with the folic acid-negative cell lines as well as the effective inhibition of folic acid receptor using free folic acid substrate. The outcome of the present study suggests that the fabricated cysteamine–folic acid-conjugated silver nanoparticles could be utilized as a potential contrast agent for molecular CT imaging. This information can be taken into consideration for applying AgNPs in enhancing radiation dose where nanoparticles containing greater X-ray attenuation were applied.
- Subjects
SILVER nanoparticles; CONTRAST media; COMPUTED tomography; FOLIC acid; ELECTRON spectroscopy; RAMAN scattering; POSITRON emission
- Publication
Biotechnology & Bioprocess Engineering, 2024, Vol 29, Issue 1, p185
- ISSN
1226-8372
- Publication type
Article
- DOI
10.1007/s12257-024-00017-5