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- Title
Analysis of the Expression of mTOR in Tissues of Females of Species Mesocricetus auratus Infected by Zika Virus.
- Authors
de Souza Pereira, Luan Filipe; Correa de Oliveira, Edivaldo Herculano; Fabiane Lopes de Melo, Karla; Canindé Ferreira de Luna, Francisco; Santos Franco, Edna Cristina; da Costa Vasconcelos, Pedro Fernando; Moraes Casseb, Samir Mansour
- Abstract
Arboviruses are recognized by the World Health Organization (WHO) as a major public health problem, due to their growing territorial spread and the great need for preventive and control actions, which are increasingly complex. Among the arboviruses that present the greatest circulation is the Zika virus (ZIKV). Thus, this work aims to evaluate the expression of mammalian Target of Rapamycin (mTOR) in tissues of females of the species Mesocricetus auratus infected with the Zika virus. The samples used in this study come from a larger project entitled "Experimental Zika virus infection in golden hamsters (Mesocricetus auratus)" from the sexually transmitted group, previously approved by the Ethics Committee on Animal Use (CEUA) of Evandro Chagas Institute with registration number 24/2016. The samples are a total of 63 samples, divided between ZIKV-infected and non-infected animals. This study showed how Zika virus may be related to mTOR 1 and mTOR 2 expressions. The comparative results to viral load emphasize the correlation between the virus and mTOR. Such correlation is of importance to ZIKV, for protein regulation pathways and virus interference on those pathways may turn out to be a factor related to its pathogenic mechanism.
- Subjects
WORLD Health Organization; ZIKA virus infections; GOLDEN hamster; ZIKA virus; SPECIES; VIRAL load
- Publication
Systematic Reviews in Pharmacy, 2022, Vol 13, Issue 11, p756
- ISSN
0975-8453
- Publication type
Article
- DOI
10.31858/0975-8453.13.11.756-760