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- Title
Rapid diurnal variation of serous retinal detachment during BRAF and MEK inhibitor treatment: A case series.
- Authors
Bravetti, Giorgio Enrico; Muggler, Kevin; Ben Aissa, Assma; Thumann, Gabriele; Malclès, Ariane
- Abstract
This article presents two case studies of patients with metastatic melanoma who experienced daily fluctuations of serous retinal detachment (SRD) while being treated with a combination of encorafenib and binimetinib. The patients reported acute blurred vision that worsened in the morning and resolved by noon. Ophthalmologic examinations and scans revealed an increase in SRD between 8 and 11 AM, followed by complete resolution by 12 PM. The fluctuations persisted throughout the day and were observed during follow-up visits. Despite the subjective complaints, the treatment was not discontinued due to preserved visual acuity and the medications being the last-line therapy for metastatic melanoma. The authors suggest that the timing and dosage of the medication may be correlated with the rapid fluctuation of SRD, and emphasize the importance of appropriate follow-up for patients undergoing this therapy.
- Subjects
RETINAL detachment; BRAF genes; PROLIFERATIVE vitreoretinopathy; ACUTE kidney failure; UVEA cancer; MITOGEN-activated protein kinases
- Publication
Acta Ophthalmologica (1755375X), 2024, Vol 102, Issue 4, pe651
- ISSN
1755-375X
- Publication type
Article
- DOI
10.1111/aos.16639