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- Title
Long-term survival in low-grade endometrial stromal sarcoma with childbirth and multidisciplinary treatment: a case report.
- Authors
Osamu Maeda; Suzuko Moritani; Shu Ichihara; Takami Inoue; Yutaka Ishihara; Shinichi Yamamoto; Makoto Ito; Yoko Matsumura; Kumiko Sugiyama; Maiko Horio; Ikuyo Kondo; Maeda, Osamu; Moritani, Suzuko; Ichihara, Shu; Inoue, Takami; Ishihara, Yutaka; Yamamoto, Shinichi; Ito, Makoto; Matsumura, Yoko; Sugiyama, Kumiko
- Abstract
<bold>Introduction: </bold>Low-grade endometrial stromal sarcoma is very rare and difficult to diagnose in the early stage. A standard treatment has not been established. In this case report of a patient with long-term survival, we describe an effective treatment for advanced low-grade endometrial stromal sarcoma.<bold>Case Presentation: </bold>A 24-year-old Japanese woman who presented with prolonged menstruation was diagnosed with leiomyoma on the basis of a specimen resected transvaginally. She underwent ten resections in 10 years without a malignancy diagnosis. During this period, she gave birth. At age 34 years, she visited our hospital, complaining of lower abdominal pain. A 10cm tumor was detected behind her uterus. The disease was diagnosed as an advanced malignant ovarian tumor before surgery. A laparotomy was performed, with many remnants left in the abdominal cavity. The final diagnosis was advanced low-grade endometrial stromal sarcoma. After 12 cycles of gemcitabine and docetaxel combination chemotherapy, the tumor disappeared completely. A retrospective pathological review of the specimens resected transvaginally showed that the tumors included low-grade endometrial stromal sarcoma elements. When the patient was age 42 years, the sarcoma recurred. It was detected around the right diaphragm and liver. Despite administration of gemcitabine and docetaxel, ascites and pleural effusion accumulated. Administration of medroxyprogesterone acetate, leuprorelin acetate, and anastrozole gradually reduced the ascites and pleural effusion. In addition to the three hormone drugs, 18 cycles of paclitaxel and carboplatin were administered. The patient recovered from her critically ill state and is currently alive with reduced tumor at age 45 years.<bold>Conclusions: </bold>Our patient with low-grade endometrial stromal sarcoma whose disease began in her youth gave birth and experienced long-term survival with surgery, chemotherapy, and hormone therapy.
- Subjects
TREATMENT of endometrial cancer; SARCOMA; TUMOR classification; CHILDBIRTH; RARE diseases; ONCOLOGY; ANTINEOPLASTIC agents; CANCER treatment; HETEROCYCLIC compounds; ORGANIC compounds; ENDOMETRIAL tumors; BIOPSY; CANCER relapse; COMPUTED tomography; DIAGNOSIS; TUMOR treatment; THERAPEUTICS
- Publication
Journal of Medical Case Reports, 2015, Vol 9, p1
- ISSN
1752-1947
- Publication type
journal article
- DOI
10.1186/s13256-015-0719-0