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- Title
Comparison of Akt Expression in the Cerebrum and Cerebellum of Newborn Mus musculus Exposed to Physical Stress and Psychological Stress During Pregnancy.
- Authors
Angesti, Herlina Puji; Joewono, Hermanto Tri; Widjiati
- Abstract
Introduction: Prenatal stress prevalence is almost half of the population of pregnant women worldwide. Stress will stimulate glucocorticoids which can disrupt the PI3K-Akt cascade. PI3K-Akt deficiency will cause impaired fetal brain growth and development. Objective: To compare the Akt expression in the cerebrum and cerebellum of newborn Mus musculus exposed to physical stress, psychological stress, the combination of psychological and physical stress, and without stress exposure. Method: This study was experimental laboratory research. Twenty-four female mice were used as samples and divided into four groups: physical stress exposure group, psychological stress exposure group, the combination of psychological and physical stress exposure group, and control group. Akt expression was tested by immunohistochemistry (IHC) staining. Statistical analysis used the One Way Anova and Kruskal Wallis test. Results: There were significant differences in cerebrum Akt expression (p = 0.008) and cerebellum Akt expression (p = 0.047) between the control and stress exposure groups. Conclusion: There were statistically significant decreases in mean Akt expression in the cerebrum and cerebellum of newborn Mus musculus exposed to stress during pregnancy.
- Subjects
PHYSIOLOGICAL stress; PSYCHOLOGICAL stress; NEWBORN infants; CEREBELLUM; FETAL brain; MICE; BIRTH weight
- Publication
Indian Journal of Forensic Medicine & Toxicology, 2021, Vol 15, Issue 4, p1440
- ISSN
0973-9122
- Publication type
Article
- DOI
10.37506/ijfmt.v15i4.18064