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- Title
Hepato-nephroprotective Role of Lepidium sativum against Oxidative Stress Induced by Dexamethasone in Rats.
- Authors
Abraheem Alsadee, Sawsan Agbashee
- Abstract
The current research was prepared to explore the hepato-nephroprotective effect of Lepidium sativum seed aquatic extract against oxidative stress stimulated by dexamethasone in rats. Animals were classified as follows; group one was used as control while groups 2, 3 and 4 were treated orally with Lepidium sativum seed extract (LSSE; 20 mg/kg, daily), interperitoneally with dexamethasone (DEX; 1 mg/kg BW) and LSSE plus DEX for 14 days, respectively. Administration of DEX elevated thiobarbituric acid reactive substances (TBARS), hydrogen peroxide (H2O2), and kidney and liver function biomarkers level, and lactate dehydrogenase activity. While enzymatic (SOD, CAT, GPx, GR, GST) and non-enzymatic (GSH) antioxidants, protein content, and alkaline phosphatase activity were significantly decreased. Otherwise, rats supplemented with LSSE singly declined lipid peroxidation and improved most of the studied parameters. Moreover, rats pretreated with LSSE then received DEX showed significant alleviation in lipid peroxidation, antioxidant status and biochemical indices with respect to DEX treated group. Conclusively, LSSE has beneficial protective effects and has the capability to counteract the harmful influence of DEX. So, Lepidium sativum might represent a novel approach in the therapy of dexamethasone because of its antioxidant properties.
- Subjects
OXIDATIVE stress; LEPIDIUM; DEXAMETHASONE; OXIDANT status; LACTATE dehydrogenase
- Publication
Indian Journal of Forensic Medicine & Toxicology, 2021, Vol 15, Issue 1, p2643
- ISSN
0973-9122
- Publication type
Article
- DOI
10.37506/ijfmt.v15i1.13797