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- Title
Genetic Modification of Mitochondrial DNA in Cancer Cells.
- Authors
Al-Oubaidy, Shaimaa A.; Mekkey, Asmaa Mohammed; Alwaeli, Ahmed Zuhair
- Abstract
Mitochondria is one of the most energy source in the cells, in addition to DNA encoded to several genes which relatively associated with several disease, researchers proved the role of mitochondrial in energy demand to tumor cells in addition to mitochondrial DNA role in cancer initiation and development. The present review explained different objectives related with the mitochondrial role in tumor incidence ; these included Tumor cells energy demands, Mitochondrial Mutations redundancy and allocation, Genetic disparate natural Selection in Tumor initiation, Mitochondrial Modifications Clinical Translations in Cancer, Association Mitochondria, epigenetics and Cancer and finally Injury of Mitochondria in Cancer. The present review concluded that the most important role of mitochondrial as cells an organelles for energy suppliers to tumor cells metastasis and immorality also the mutations of mtDNA and their role in carcinogenesis were well proved in different cancer types.
- Subjects
MITOCHONDRIAL DNA; ORGANELLES; CANCER cells; NATURAL selection; MITOCHONDRIAL DNA abnormalities; MITOCHONDRIA; METASTASIS
- Publication
Indian Journal of Forensic Medicine & Toxicology, 2021, Vol 15, Issue 1, p1538
- ISSN
0973-9122
- Publication type
Article
- DOI
10.37506/ijfmt.v15i1.13630