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- Title
Thyroid Autoimmunity and Recurrent Miscarriage.
- Authors
Ticconi, Carlo; Giuliani, Emma; Veglia, Manuela; Pietropolli, Adalgisa; Piccione, Emilio; Di Simone, Nicoletta
- Abstract
Citation Ticconi C, Giuliani E, Veglia M, Pietropolli A, Piccione E, Di Simone N. Thyroid autoimmunity and recurrent miscarriage. Am J Reprod Immunol 2011; 66: 452-459 Problem To investigate the role of antithyroid autoantibodies (ATA) in recurrent miscarriage (RM). Methods In this case-control study, a total of 160 women with RM and 100 healthy women were investigated for the presence of serum ATA directed against thyreoglobulin (TG-Ab), thyroid peroxidase (TPO-Ab) and TSH receptor (TSHr-Ab), which were determined by either chemiluminescence or radioimmunoassay. Results Antithyroid autoantibodies were detected in 46 (28.75%) women with RM and in 13 (13%) women of the control group ( P < 0.05). The frequencies for TG-Ab and TPO-Ab were higher in RM than in control women. Among the women of RM group, 91.3% of ATA+ women were positive also for other autoantibodies. The majority of study women were euthyroid. Conclusions Antithyroid autoantibodies, particularly TG-Ab, are associated with RM and could be an expression of a more general maternal immune system abnormality leading to RM. ATA could have a role in RM irrespective of thyroid hormone status.
- Subjects
AUTOANTIBODIES; RECURRENT miscarriage; IMMUNOGLOBULINS; MISCARRIAGE; CHEMILUMINESCENCE
- Publication
American Journal of Reproductive Immunology, 2011, Vol 66, Issue 6, p452
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/j.1600-0897.2011.01021.x