We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Novel one-pot synthesis of 1-alkyl-2-(aryloxy)methyl-1H-pyrrolo[2,3-b]quinoxalines via copper-free Sonogashira coupling reaction.
- Authors
Keivanloo, Ali; Fakharian, Mahsa; Nabid, Mohammad Reza; Amin, Amir Hossein
- Abstract
Abstract: A novel, simple, and efficient protocol is described for the synthesis of 1-alkyl-2-(aryloxy)methyl-1H-pyrrolo[2,3-b]quinoxalines via the one-pot reaction of phenol or 2-naphthol derivatives, propargyl bromide, and N-alkyl-3-chloroquinoxaline-2-amines in the presence of palladium catalyst. This one-pot reaction is carried out in the absence of any copper salt at room temperature. The reaction product is dependent on the nature of the base used. The use of morpholine, as the base, affords the final cyclized product, and triethylamine only gives the coupling product.Graphical abstract:
- Subjects
QUINOXALINES; SONOGASHIRA reaction; COPPER compounds; PHENOL analysis; NAPHTHOL derivatives; PALLADIUM catalysts
- Publication
Journal of the Iranian Chemical Society, 2019, Vol 16, Issue 1, p151
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/s13738-018-1492-y