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- Title
Genetic association analysis using weighted false discovery rate approach on Genetic Analysis Workshop 18 data.
- Authors
Xin Qiu; Xiaowei Shen; Espin-Garcia, Osvaldo; Azad, Abul Kalam; Liu, Geoffrey; Wei Xu
- Abstract
In a genome-wide association study, association between disease trait and hundreds of thousands of genetic markers are tested. Several methods have been proposed to control the false discovery rate in such highthroughput data to adjust for multiple hypotheses testing. For Genetic Analysis Workshop 18, we applied the method of false discovery rate control with p value weighting on family-based association tests on quantitative trait to detect association between single-nucleotide polymorphisms (SNPs) and mean arterial pressure. This method can improve statistical power by incorporating independent but relevant information about the research objective. Using the real genetic and phenotype data of chromosome 3 from Genetic Analysis Workshop 18, 1 SNP from gene CACNA2D3 was found to have significant association with mean arterial pressure.
- Subjects
GENETIC databases; GENETIC markers; SINGLE nucleotide polymorphisms; PHENOTYPES; STATISTICAL methods in genetics
- Publication
BMC Proceedings, 2014, Vol 9, Issue Supplement 5, p1
- ISSN
1753-6561
- Publication type
Article
- DOI
10.1186/1753-6561-8-S1-S76