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- Title
Presynaptic‘Ca<sub>v</sub>2.3-containing’ E-type Ca<sup>2+</sup> channels share dual roles during neurotransmitter release.
- Authors
Kamp, M. A.; Krieger, A.; Henry, M.; Hescheler, J.; Weiergräber, M.; Schneider, T.
- Abstract
Ca2+ influx into excitable cells is a prerequisite for neurotransmitter release and regulated exocytosis. Within the group of ten cloned voltage-gated Ca2+ channels, the Cav2.3-containing E-type Ca2+ channels are involved in various physiological processes, such as neurotransmitter release and exocytosis together with other voltage-gated Ca2+ channels of the Cav1, Cav2 and Cav3 subfamily. However, E-type Ca2+ channels also exhibit several subunit-specific features, most of which still remain poorly understood. Cav2.3-containing R-type channels (here called‘E-type channels’) are also located in presynaptic terminals and interact with some synaptic vesicle proteins, the so-called SNARE proteins, although lacking the classical synprint interaction site. E-type channels trigger exocytosis and are also involved in long-term potentiation. Recently, it was shown that the interaction of Cav2.3 with the EF-hand motif containing protein EFHC1 is involved in the aetiology and pathogenesis of juvenile myoclonic epilepsy.
- Subjects
PRESYNAPTIC receptors; NEUROTRANSMITTER receptors; NEURAL transmission disorders; EXOCYTOSIS; CELL physiology; CELL receptors
- Publication
European Journal of Neuroscience, 2005, Vol 21, Issue 6, p1617
- ISSN
0953-816X
- Publication type
Article
- DOI
10.1111/j.1460-9568.2005.03984.x