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- Title
Enantiomeric N‐(tert‐Butylsulfinyl) Polyfluoroalkyl Aldimines in aza‐Henry Reaction: Effective Route to Chiral Polyfluoroalkyl Nitroamines and Diamines.
- Authors
Rassukana, Yuliya V.; Cherednichenko, Alona S.; Shishkina, Svitlana V.; Onys'ko, Petro P.
- Abstract
A highly diastereoselective addition of nitromethane to the C=N bond of enantiomeric fluorine containing Ellman's aldimines, RFCH=NS(O)tert‐Bu (RF=CF3, CF2Br, C2F5, HC2F4), has been successfully developed. The synthetic potential of the resulting β‐nitrosulfinylamides was demonstrated through their conversion into optically active α‐fluoroalkylated 1,3‐nitroamines, 1,3‐diamines, and 4‐fluoroalkylated imidazolidin‐2‐ones.
- Subjects
FLUOROALKYL compounds; NITROAMINES; NITROMETHANE; ALDIMINES; DIAMINES; FLUORINE
- Publication
European Journal of Organic Chemistry, 2023, Vol 26, Issue 33, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202300607