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- Title
High-Throughput Screening of Escherichia coli O157:H7 Pathogenic Genes via Pathway Enrichment and Operon Analysis.
- Authors
Guangxin Yuan; Jia Fu; Liping An; Yan Zhuang; Yu Wang; Yunfeng Song; Zijing Qiao; Xiaolong Wang; Yufei Tian; Xiao Han; Peige Du; Guangyu Xu
- Abstract
Background: About thirty thousand people globally die every day from infectious diarrhea, mostly caused by pathogenic Escherichia coli (E. coli) O157:H7. Methods: In order to search for clinical diagnostic biomarkers and novel drug targets for infectious diarrhea, we used a bibliometric method to collect pathogenic genes of E. coli O157:H7 and performed a functional analysis of the important pathogenic genes by pathway enrichment and operon analysis. Results: We found 364 pathogenic genes which may be involved in infection with E. coli O157:H7 including 50 new specific pathogenic genes. It is possible that these newly found pathogenic genes will be of great importance in the treatment of E. coli O157:H7 infected diseases and the discovery of novel diagnostic biomarkers. Conclusions: Our findings also lay a theoretical foundation for the control, diagnosis, and prognosis of pathogenic E. coli related diseases.
- Subjects
BACTERIAL genetics; TREATMENT of escherichia coli diseases; ENTEROBACTERIACEAE diseases; DIAGNOSIS of escherichia coli diseases
- Publication
Clinical Laboratory, 2017, Issue 10, p1599
- ISSN
1433-6510
- Publication type
Article
- DOI
10.7754/Clin.Lab.2017.170314