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- Title
Interferon treatment for chronic hepatitis C virus infection in uremic patients.
- Authors
Koenig, Paul; Vogel, Wolfgang; Umlauft, Florian; Weyrer, Katharina; Prommegger, Rupert; Lhotta, Karl; Neyer, Ulrich; Stummvoll, Hans-Krister; Gruenewald, Kurt
- Abstract
Hepatitis C virus infection has been identified as the major cause of parenterally transmitted hepatitis. Chronic hepatitis C is a major problem in patients on maintenance hemodialysis awaiting kidney transplantation. Whereas uremia seems to predispose to chronic viral carrier status with little inflammatory activity in the liver, the change in immune status after kidney transplantation modified by immunosuppressive drugs causes acceleration of inflammatory liver disease often leading to death from liver failure. For the first time an effective therapy became available with the advent of interferon treatment for chronic hepatitis virus infection. A bulk of evidence has accumulated during the last decade showing that this therapy is of benefit in nonuremic patients with chronic hepatitis C. However, little information has been presented so far on chronically hepatitis C virus-infected uremic patients treated with interferon. Therefore, we conducted a study of interferon treatment in patients on maintenance dialysis with regard to its efficacy in suppressing viremia and tolerability of side effects. We report the result of an open multicenter trial of interferon treatment in patients on maintenance hemodialysis suffering from chronic hepatitis C virus infection. The trial was conducted by the Austrian Association of Nephrology.
- Subjects
INTERFERONS; HEPATITIS C treatment; HEMOLYTIC-uremic syndrome; HEMODIALYSIS; KIDNEY transplantation; IMMUNOSUPPRESSIVE agents
- Publication
Kidney International, 1994, Vol 45, Issue 5, p1507
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1994.197