We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Paradoxical potassium depletion: A renal mechanism for extrarenal potassium adaptation.
- Authors
Spital, Aaron; Sterns, Richard H.
- Abstract
Following nephrectomy and acute potassium loading, animals previously maintained on a high potassium diet have a smaller increment in plasma potassium than do animals on a control diet. The mechanism of this ‘extrarenal potassium adaptation’ is not known. To explore the role of potassium depletion in this process, we studied rats adapted to either a high potassium (HK) or control (C) diet. When dietary potassium was withdrawn, urinary potassium losses in HK rats greatly exceeded those in C rats for at least two days, leading to greater potassium depletion in HK than C animals. A smaller increment in plasma potassium in HK compared to C rats was seen only after prolonged fasting preceded nephrectomy and acute potassium loading. Correction of potassium depletion incurred during fasting abolished extrarenal potassium adaptation. We conclude: 1) after withdrawal of dietary potassium, urinary potassium losses are much greater in HK than in C rats: 2) if the duration of dietary potassium deprivation is sufficient, these urinary potassium losses will cause potassium-adapted animals to paradoxically become more potassium depleted than controls: and 3) this paradoxical potassium depletion may be responsible for extrarenal potassium adaptation.
- Subjects
HIGH-potassium diet; DIET therapy; POTASSIUM deficiency diseases; POTASSIUM; LABORATORY rats
- Publication
Kidney International, 1986, Vol 30, Issue 4, p532
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1986.218