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- Title
Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting.
- Authors
Naganawa, Shinji; Toshiki Nakane; Hisashi Kawai; Toshiaki Taoka; Hirokazu Kawaguchi; Katsuya Maruyama; Katsutoshi Murata; Körzdörfer, Gregor; Pfeuffer, Josef; Nittka, Mathias; Michihiko Sone
- Abstract
Purpose: It has been reported that leakage of intravenously administered gadolinium-based contrast agents (IV-GBCAs) into the cerebrospinal fluid (CSF) from the cortical veins even in healthy subjects can be detected using a highly sensitive pulse sequence such as heavily T2-weighted 3D fluid-attenuated inversion recovery and 3D-real inversion recovery (IR). The purpose of this study was to evaluate the feasibility of MR fingerprinting to detect GBCA leakage from the cortical veins after IV-GBCA. Materials: Fourteen patients with suspected endolymphatic hydrops (EH) who received a single dose of IV-GBCA (39-79 years old) were included. The real IR images as well as MR fingerprinting images were obtained at 4 h after IV-GBCA. T1 and T2 values were obtained using MR fingerprinting and analyzed in ROIs covering intense GBCA leakage, and non-leakage areas of the CSF as determined on real IR images. The scan time for real IR imaging was 10 min and that for MR fingerprinting was 41 s. Results: The mean T1 value of the ROI in the area of GBCA leakage was 2422 ± 261 ms and that in the nonleakage area was 3851 ± 235 ms (P < 0.01). There was no overlap between the T1 values in the area of GBCA leakage and those in the non-leakage area. The mean T2 value in the area of GBCA leakage was 319 ± 90 ms and that in the non-leakage area was 670 ± 166 ms (P < 0.01). There was some overlap between the T2 values in the area of GBCA leakage and those in the non-leakage area. Conclusion: Leaked GBCA from the cortical veins into the surrounding CSF can be detected using MR fingerprinting obtained in <1 min.
- Subjects
GADOLINIUM; CEREBROSPINAL fluid; MAGNETIC resonance imaging; HUMAN fingerprints; MENIERE'S disease
- Publication
Magnetic Resonance in Medical Sciences, 2020, Vol 19, Issue 2, p141
- ISSN
1347-3182
- Publication type
Article
- DOI
10.2463/mrms.mp.2019-0048