We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Left Ventr icular Three-Dimensional Quadripolar Lead Acute Clinical Study: The LILAC Study.
- Authors
PHILIPPON, FRANÇOIS; LIU, LILI; FUNG, JEFFREY WING ‐ HONG; DEHARO, JEAN ‐ CLAUDE; ANSELME, FREDERIC; DELNOY, PETER PAUL; CRIJNS, HARRY; MORILLO, CARLOS A.; KRAHN, ANDREW D.; GUTLEBEN, KLAUS; DELUMEAU, JULIEN; MOLIN, FRANCK
- Abstract
Aims This multicenter acute clinical study was designed to verify novel three-dimensional (3D) quadripolar lead designs that can achieve ≤2.5 V average pacing capture threshold (PCT) not only at the apex, but also at the base of the left ventricle with phrenic nerve stimulation (PNS) avoidance for cardiac resynchronization. Methods During the implant procedure, up to two different left ventricular investigational leads were introduced and tested in the same target coronary vein based on the coronary sinus venogram in a wedged and unwedged position. Adverse events were collected in 30 days following the procedure. Results Eighty-seven leads were tested in 50 patients. When the best performing spiral electrode was chosen from each lead testing, the average of the best PCT on spiral in a wedged position was similar to the unwedged position (1.7 ± 1.5 V vs 1.9 ± 1.5 V, P = ns) and was similar to the wedged tip electrode average PCT (1.7 ± 1.5 V vs 1.6 ± 1.6 V, P = ns). In the majority of patients (89-96%), pacing was achievable in a mid-basal ventricular location without PNS. Conclusions This acute study demonstrated that a 3D quadripolar spiral lead design can achieve acceptable PCTs and avoid PNS without repositioning the lead at implant in the vast majority of patients. It also demonstrated that this lead design can achieve mid-basal ventricular stimulation with low PCT and good acute stability.
- Subjects
CARDIAC pacing; ANALYSIS of variance; ELECTRODES; ELECTROPHYSIOLOGY; ARTIFICIAL implants; LONGITUDINAL method; MEDICAL cooperation; PHRENIC nerve; RESEARCH; T-test (Statistics); VENOGRAPHY; PILOT projects; PRODUCT design; DATA analysis software; DESCRIPTIVE statistics; EQUIPMENT &; supplies
- Publication
Pacing & Clinical Electrophysiology, 2015, Vol 38, Issue 4, p438
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1111/pace.12584