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- Title
Isolated Tramadol Overdose Associated with Brugada ECG Pattern.
- Authors
COLE, JON B.; SATTIRAJU, SRINIVASAN; BILDEN, ELISABETH F.; ASINGER, RICHARD W.; BERTOG, STEFAN C.
- Abstract
Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219-e221)
- Subjects
DRUG overdose; ELECTROCARDIOGRAPHY; ARTIFICIAL respiration; MENTAL depression; DRUG toxicity; ECHOCARDIOGRAPHY; HIGH performance liquid chromatography; NALOXONE; SUICIDE; BRUGADA syndrome; TRAMADOL; CORONARY angiography; DIAGNOSIS
- Publication
Pacing & Clinical Electrophysiology, 2012, Vol 35, Issue 8, pe219
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1111/j.1540-8159.2010.02924.x