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- Title
Metabolic bone markers can be related to preserved insulin secretion in children with newly diagnosed type 1 diabetes.
- Authors
Szymańska, Małgorzata; Michałus, Izabela; Kaszkowiak, Marcin; Wyka, Krystyna; Chlebna-Sokół, Danuta; Fendler, Wojciech; Jakubowska-Pietkiewicz, Elżbieta; Młynarski, Wojciech; Szadkowska, Agnieszka; Zmysłowska, Agnieszka
- Abstract
Introduction: Type 1 diabetes (T1D) may be associated with numerous complications including bone metabolism disorders. The aim of the study was to evaluate the bone metabolism markers twice in children with a newly diagnosed T1D and after an average of seven months of its duration in relation to parameters of the clinical course of diabetes. Material and methods: In 100 T1D patients and 52 control subjects, the following bone turnover markers were evaluated: osteocalcin - OC, osteoprotegerin - OPG, sRANKL, and deoxypyridoline in urine - DPD and DXA examination was also performed. Results: Lower OC concentration at T1D onset in comparison to controls (p < 0.001) and its increase during follow-up (p < 0.001) was observed. The OPG concentration was elevated at T1D onset as compared to the control group (p = 0.024) and decreased thereafter (p < 0.001). The s-RANKL level increased during follow-up (p < 0.001) and was lower than in controls (p < 0.001). Urine DPD concentration also increased during follow-up in the T1D patient group (p < 0.001) and was higher in comparison to the control group (p = 0.021). BMD-TBLH was higher in the control group as compared to patients both at T1D onset (p = 0.025) and in follow-up observation (p = 0.034). Moreover, OPG correlated positively with glycated haemoglobin (HbA1c) (p = 0.004) and negatively with fasting C-peptide level (p = 0.046) and BMI Z-score (p = 0.003), whereas s-RANKL correlated positively with both fasting (p < 0.001) and stimulated C-peptide levels (p < 0.001). Conclusions: Bone metabolism disorders observed at T1D onset in children and modified after reaching the metabolic control of the disease seem to be most strongly associated with preserved insulin secretion.
- Subjects
TYPE 1 diabetes; BONES; METABOLIC bone disorders; SECRETION; INSULIN; OSTEOCALCIN; TERIPARATIDE; BONE regeneration
- Publication
Pediatric Endocrinology, Diabetes & Metabolism, 2020, Vol 26, Issue 1, p10
- ISSN
2083-8441
- Publication type
Article
- DOI
10.5114/pedm.2020.94391