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- Title
Fusariosis en pacientes con cáncer: serie de 13 casos y revisión de la literatura.
- Authors
Isabel Cuervo-Maldonado, Sonia; Camilo Álvarez-Rodríguez, José; Leonardo Cubides, Cristian; Camilo Barrera, Juan; Diego Montañez-Abril, Juan; Paola Vergara-Vela, Erika; Humberto Saavedra-Trujillo, Carlos; José López-Mora, María; Elena Mora-Figueroa, Gloria; Celis-Ramírez, Adriana; Mary Jaramillo-Calle, Rose; Parra-Medina, Rafael
- Abstract
The fusariosis is an opportunistic mycosis caused by Fusarium spp. Its clinical presentation depends on the immunological status of the host, especially in patients with hematooncological diseases, whose manifestations vary from localized to invasive fungal infections. Skin or blood culture helps to guide combined antifungal treatment with amphotericin B and voriconazole. Here, we present 13 cases in a period of eleven years of patients with cancer who developed disseminated fusariosis and their outcomes, together with a review of the related literature. In this series of cases, mortality was 61.5 % (8/13), despite the use of the antifungal. Out of the 13 cases, 11 had hematological neoplasia and 2 solid neoplasia. The most determinant risk factor was profound neutropenia. Skin involvement and positive blood cultures in most cases allowed combined treatment prescription. Persistent febrile neutropenia associated with skin lesions, onychomycosis, nodules, or lung masses lead to suspicion of Fusarium spp. fungal invasive infection. The aim of this series of cases is to remind healthcare professionals that oncological patients with deep and persistent febrile neutropenia can develop fusariosis.
- Subjects
MEDICAL personnel; FUSARIOSIS; MYCOSES; AMPHOTERICIN B; SYMPTOMS; FEBRILE neutropenia; ONYCHOMYCOSIS
- Publication
Biomédica: Revista del Instituto Nacional de Salud, 2023, Vol 43, p41
- ISSN
0120-4157
- Publication type
Article
- DOI
10.7705/biomedica.6925