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- Title
Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases: Potential Role in Macrophage-Mediated Inflammatory Diseases.
- Authors
Yuki Murakami; Masato Hoshi; Yukio Imamura; Yuko Arioka; Yasuko Yamamoto; Kuniaki Saito
- Abstract
Indoleamine 2,3-dioxygenase 1 (IDO1), the L-tryptophan-degrading enzyme, plays a key role in the immunomodulatory effects on several types of immune cells. Originally known for its regulatory function during pregnancy and chronic inflammation in tumorigenesis, the activity of IDO1 seems to modify the inflammatory state of infectious diseases. The pathophysiologic activity of L-tryptophan metabolites, kynurenines, is well recognized. Therefore, an understanding of the regulation of IDO1 and the subsequent biochemical reactions is essential for the design of therapeutic strategies in certain immune diseases. In this paper, current knowledge about the role of IDO1 and its metabolites during various infectious diseases is presented. Particularly, the regulation of type I interferons (IFNs) production via IDO1 in virus infection is discussed. This paper offers insights into new therapeutic strategies in the modulation of viral infection and several immune-related disorders.
- Subjects
COMMUNICABLE diseases; INDOLEAMINE 2,3-dioxygenase; TRYPTOPHAN metabolism; MACROPHAGES; INFLAMMATORY mediators; IMMUNOREGULATION; CELLULAR immunity
- Publication
Mediators of Inflammation, 2013, Vol 2013, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2013/391984