We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Urea channel inhibitors: a new functional class of aquaretics.
- Authors
Knepper, Mark A; Miranda, Carlos A
- Abstract
Using large-scale small-molecule screening techniques, Li et al. have identified a compound that inhibits the UT-B urea channel. They propose that this or similar compounds could be used as aquaretic agents to increase water excretion without changes in electrolyte excretion. Such compounds would potentially be useful in treatment of hyponatremic disorders. Here we review the physiological basis for the action of urea channel inhibitors in the kidney and assess their clinical potential.
- Subjects
UREA; URINALYSIS; NITROGEN excretion; BENZOYLPHENYL ureas; DIURON
- Publication
Kidney International, 2013, Vol 83, Issue 6, p991
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2013.94