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- Title
Bioavailable vitamin D in chronic kidney disease.
- Authors
Brown, Alex J; Coyne, Daniel W
- Abstract
Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.
- Subjects
VITAMIN D metabolism; BIOAVAILABILITY; CHRONIC kidney failure; KIDNEY diseases; METABOLITES; CARRIER proteins; ALBUMINS
- Publication
Kidney International, 2012, Vol 82, Issue 1, p5
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2012.135