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- Title
The effect of hormone replacement therapy on cognitive function in post-menopausal women.
- Authors
R. Lavi; G.M. Doniger; E. Simon; D. Hochner-Celnikier; A. Zimran; D. Elstein
- Abstract
Background: Despite interest in causes of dementia in older persons, particularly in post-menopausal women, it is unclear whether hormone replacement therapy (HRT) is a risk factor. Aim: To assess cognitive function in post-menopausal women with high educational status receiving HRT, compared to non-users. Design: Cognitive functioning was assessed with in women aged 55â60 years with at least university-level education, using the Mindstreams system, a computerized cognitive battery with multiple domains. Results: Of 165 women meeting the inclusion/exclusion criteria, 82 women (49.7%) declined participation. Of the remaining 83, 40 (48.2%) had never received HRT; the remainder was divided into women receiving 5â9 years HRT (n = 29)versus those with 10 years HRT (n = 11). There were no statistically significant differences between HRT users and non-users in global scores or sub-domains of cognitive functioning, and no difference between those women receiving HRT for 5â9 years vs. 10 years. Discussions: Long-term HRT does not appear to impair cognitive functioning in highly-educated women. Recommendations regarding post-menopausal HRT should be made on an individual basis.
- Subjects
DEMENTIA; NEUROBEHAVIORAL disorders; PSYCHOSES; THERAPEUTICS
- Publication
QJM: An International Journal of Medicine, 2007, Vol 100, Issue 9, p567
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcm065