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- Title
Enhancing decellularized aortic allografts for paediatric valve replacement: insights and future directions.
- Authors
Wei, Shixiong; Zhang, Yiyuan; Lv, Guoyue
- Abstract
The article discusses the use of decellularized aortic allografts (DAH) in pediatric valve replacement surgeries. The research highlights the positive outcomes of using DAH, including a high survival rate and functional valves over a 5-year follow-up period. However, the study also raises questions about the immune response elicited by DAH and the need for further scientific exploration in this area. The article suggests that future research should focus on refining decellularization techniques to minimize immunogenicity, exploring bioengineering approaches to reduce immune reactions, and developing targeted immunosuppressive therapies. Overall, the article emphasizes the potential of decellularized aortic allografts in regenerative medicine and the importance of a multidisciplinary approach to overcome challenges in this field.
- Subjects
HOMOGRAFTS; AORTA; PEDIATRICS; AORTIC valve transplantation; VALVES; PEDIATRIC surgeons
- Publication
European Journal of Cardio-Thoracic Surgery, 2024, Vol 65, Issue 5, p1
- ISSN
1010-7940
- Publication type
Article
- DOI
10.1093/ejcts/ezae198