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- Title
Now exists a scientific proof of increased lymphatic pumping using octreotide: what is its actual role in the chylothorax healing process?
- Authors
Pimpec-Barthes, Françoise Le; Iaffaldano, Amedeo Giuseppe Rendina; Masmoudi, Hicham; Al-Zreibi, Charles
- Abstract
This article discusses the role of the lymphatic system in the healing process of chylothorax, a condition characterized by the leakage of chyle into the pleural cavity. The lymphatic system, composed of contractile and valvular vessels, plays a crucial role in maintaining the body's homeostasis. Chylothorax can be caused by direct trauma to the lymphatic vessels or increased pressure due to obstruction. The article highlights the challenges in managing chylothorax and emphasizes the importance of reducing chyle production, promoting pleural emptying, and maintaining good nutritional status. The use of somatostatin analogues, such as octreotide, has been commonly used in treating chylous leakages, although the mechanisms of action are not fully understood. A recent study found that octreotide increased lymphatic contractility in the thoracic duct, but did not have the same effect on peripheral lymphatic vessels. The article concludes by calling for further research on the lymphatic system and its role in various pathologies.
- Subjects
CHYLOTHORAX; HEALING; THORACIC duct; LYMPHANGIOGRAPHY; LOW-fat diet
- Publication
European Journal of Cardio-Thoracic Surgery, 2024, Vol 65, Issue 2, p1
- ISSN
1010-7940
- Publication type
Article
- DOI
10.1093/ejcts/ezad416