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- Title
In vivo dopaminergic and behavioral responses to acute cocaine are altered in adenosine A<sub>2A</sub> receptor knockout mice.
- Authors
Wells, Lisa; Opacka-Juffry, Jolanta; Fisher, Donald; Ledent, Catherine; Hourani, Susanna; Kitchen, Ian
- Abstract
Adenosine, acting on adenosine A2A receptors (A2ARs), regulates addictive processes induced by drugs of abuse. This study investigates the role of A2A adenosine receptors in neurochemical and behavioral responses to an acute cocaine challenge. Changes in the extracellular levels of dopamine (DA) in the nucleus accumbens (NAc) of mice lacking A2A adenosine receptors and wild type (WT) littermates after an acute cocaine (20 mg/kg) administration were evaluated by in vivo microdialysis studies. Locomotor effects induced by cocaine were measured during the microdialysis procedure. Cocaine-evoked increases in extracellular DA were not sustained in mice lacking A2ARs in comparison with wild-type mice ( P < 0.05). Cocaine administration significantly increased ambulatory activity in both genotypes. However, overall locomotor activity was further increased, whereas rest and small local movement measures were significantly attenuated in the A2AR knockout mice compared with WT littermates ( P < 0.05). Our findings support an important role for adenosine A2AR in modulating the acute effects of cocaine, as demonstrated by the decrease in cocaine-evoked dopaminergic transmission in the NAc. Furthermore, the results support an important antagonistic role of A2AR in vivo in regulating psychostimulant-induced hyperlocomotion. Synapse, 2012. © 2011 Wiley Periodicals, Inc.
- Publication
Synapse, 2012, Vol 66, Issue 5, p383
- ISSN
0887-4476
- Publication type
Article
- DOI
10.1002/syn.21527