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- Title
BLOOD CONSERVATION STRATEGIES.
- Authors
Shander, Aryeh
- Abstract
Increasing concerns over the widespread use of blood transfusions have prompted interest in blood conservation strategies, including various pharmacologic agents, as well as numerous devices and techniques. This article explores the currently available blood conservation strategies and the evidence supporting their efficacy in various acute clinical settings. Pharmacologic agents, which include antifibrinolytic agents, desmopressin, erythropoiesis-stimulating agents, parenteral iron, vitamin K, and recombinant activated factor VII, can either reduce or stop bleeding, or decrease the likelihood of transfusion by raising hemoglobin. Other strategies, which have mostly been used to reduce transfusion requirements in surgical or trauma cases, include acute normovolemic hemodiluton, cell salvage, reduction of blood loss during diagnostic testing, and potentially red-cell substitutes. Also included is a discussion on areas of controversy related to blood conservation and examples of successful institution-based blood management programs.
- Subjects
BLOOD transfusion; PHARMACOLOGY; ANTIFIBRINOLYTIC agents; DESMOPRESSIN; ERYTHROPOIESIS; VITAMIN K
- Publication
Johns Hopkins Advanced Studies in Medicine, 2008, Vol 8, Issue 10, p363
- ISSN
1530-3004
- Publication type
Bibliography