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- Title
The value of the urinary protein:creatinine ratio for the detection of significant proteinuria in women with suspected preeclampsia.
- Authors
Bhide, Amar; Rana, Ritu; Dhavilkar, Mrugaya; Amodio‐Hernandez, Montserrat; Deshpande, Deepika; Caric, Vedrana
- Abstract
To explore the correlation between urinary protein:creatinine ratio and 24-h excretion of protein, we studied 149 women referred to a day assessment unit for investigations for suspected preeclampsia. Paired samples were obtained for measurement of urinary protein:creatinine ratio and 24-h protein excretion. Collection of a 24-h urine sample was validated by the daily creatinine excretion. The outcome measure was proteinuria of 300 mg/day or more. Inaccurate 24-h collection was observed in 17% of women. All women ( n = 56) with a protein:creatinine ratio >60 mg/mM had significant proteinuria. No woman with protein:creatinine ratio <18 mg/mM ( n = 20) had significant proteinuria. We recommend that a dual cut-off should be used for excluding and 'ruling in' the diagnosis of significant proteinuria. A 24-h urine collection should be used only for urinary protein:creatinine ratio values between 18 and 60 mg/mM in the detection of significant proteinuria.
- Subjects
PROTEINS in the body; PREECLAMPSIA; CREATININE; PROTEINURIA; PROTEIN research
- Publication
Acta Obstetricia et Gynecologica Scandinavica, 2015, Vol 94, Issue 5, p542
- ISSN
0001-6349
- Publication type
Article
- DOI
10.1111/aogs.12624