We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Confocal microscopy of the Peripheral Gustatory System: Comparison between Healthy Subjects and Patients Suffering from Taste Disorders during Radiochemotherapy.
- Authors
Tino Just
- Abstract
OBJECTIVES:: Laser-scanning microscopy (LSM) was used to compare taste buds and epithelia of fungiform papillae of healthy subjects with those of patients suffering from taste disorders during/after radiochemotherapy (RCT). Aim of the study was to investigate effects responsible for taste loss at a microscopic level.STUDY DESIGN:: Prospective study.METHODS:: Data from 12 healthy subjects (mean age 52.4, SD 9.5 years) were compared with those of 12 patients (mean age 54.7, SD 8.5 years) with head and neck cancer suffering from taste disorders during RCT. Four parameters from LSM were selected for analysis: 1) distance between the pore of the taste buds of fungiform papillae and the crest of the papillary vessels; 2) epithelial cells of each taste bud at 34 μm; 3), cell density, and 4) area of the taste pore at 4 μm. These data were correlated to measures of gustatory sensitivity obtained with both the validated “taste strips” test kit and electrogustometry.RESULTS:: Patients complaining from taste disorders during RCT exhibited a significant decrease of taste function assessed with both natural and electric stimuli. In these patients, we found thicker epithelia and smaller areas of the taste pores compared with healthy subjects. In 30% of those patients, no taste pores were detectable; in deeper sections, however, normal taste buds were present.CONCLUSIONS:: In conclusion, in RCT patients with taste disorders, LSM indicates changes of epithelia of fungiform papilla but no changes of the taste bud structure. Damage of the chorda tympani nerve by scattered rays, direct or indirect mucotoxic effects of chemotherapeutic agents, and covering of taste pores by epithelial cells are likely reasons for taste loss during RCT.
- Publication
Laryngoscope, 2005, Vol 115, Issue 12, p2178
- ISSN
0023-852X
- Publication type
Article