We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dropouts in sublingual allergen immunotherapy trials - a systematic review.
- Authors
Makatsori, M.; Scadding, G. W.; Lombardo, C.; Bisoffi, G.; Ridolo, E.; Durham, S. R.; Senna, G.
- Abstract
Participant dropouts can reduce the power of allergen immunotherapy clinical trials. Evaluation of the dropout rate and reasons for dropout are important not only in the planning of clinical studies but are also relevant for adherence to immunotherapy in daily clinical practice. A systematic review was carried out in order to establish the overall dropout rate among published double-blind, placebo-controlled randomized clinical trials of sublingual immunotherapy for respiratory allergic diseases. Dropouts were analysed in regards to allergen, formulation, treatment schedule, participant age, study size, number of centres and type of allergic disease. Relative dropout rates in placebo and active groups as well as reasons for dropout were also assessed. A total of 81 studies, comprising 9998 patients, were included. Dropout rates in sublingual immunotherapy controlled studies do not appear to be a major problem with a composite dropout percentage of 14% (95% CI:11.9-16). Furthermore, they are not different for active compared to placebo-treated participants. This lends support to the positive clinical outcomes seen in meta-analyses of these trials.
- Subjects
IMMUNOTHERAPY; CLINICAL trials; ALLERGENS; ALLERGY in children; SYSTEMATIC reviews; BLIND experiment
- Publication
Allergy, 2014, Vol 69, Issue 5, p571
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.12385