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- Title
A prospective study on the safety of sublingual immunotherapy in pregnancy.
- Authors
Shaikh, W. A.; Shaikh, S. W.
- Abstract
Background The aim of this study was to determine the safety of sublingual immunotherapy in pregnancy, which has not yet been reported. Methods One hundred and fifty-five patients received sublingual immunotherapy with either house dust mite ( D. farinae) or a mixture of up to five allergens during 185 pregnancies. Twenty-four patients received sublingual immunotherapy for the first time during pregnancy. Follow-up data were analysed with regard to abortion, perinatal mortality, prematurity, toxaemia and congenital malformation. Two control groups did not receive immunotherapy; group A (85 patients) received budesonide 400 μg twice daily and group B (40 patients) received rescue salbutamol inhalation. All three groups were on appropriate avoidance measures. Results Six-year follow-up data for the sublingual immunotherapy group revealed an incidence of complications less than that in the general population and a higher incidence of complications in both control groups. Conclusions This study concludes that sublingual immunotherapy is safe during pregnancy and is also safe when initiated for the first time in a pregnant patient.
- Subjects
IMMUNOTHERAPY; HOUSE dust mites; ALLERGENS; PREECLAMPSIA; HUMAN abnormalities
- Publication
Allergy, 2012, Vol 67, Issue 6, p741
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/j.1398-9995.2012.02815.x