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- Title
Evaluación in vivo de la protección que confieren los β-glucanos de Pleurotus ostreatus frente a los efectos nocivos de la ingestión de acrilamida (Parte I).
- Authors
Aguilar-Uscanga, Blanca R.; Cavazos-Garduño, Adriana; Solis-Pacheco, Josué R.; Sandoval-García, Flavio; Navarro-Hernández, Rosa E.; Serrano-Niño, Julio C.; Aguilar Uscanga, Blanca Rosa; Solís Pacheco, Josué R; Sandoval Garcia, Flavio; Navarro Hernández, Rosa Elena; Serrano Niño, Julio
- Abstract
<bold>Introduction: </bold>Introduction: acrylamide is formed in food through Maillard's reaction during thermal processing, and has been shown to be neurotoxic in humans, and a possible carcinogen. Studies have shown that β-glucans from Pleurotus ostreatus have diverse biological properties such as antioxidant and anticancer activities. Objective: the aim of this work was to evaluate the protective effect of β-glucans from Pleurotus ostreatus against the harmful effects of acrylamide consumption in mice. Methods: β-glucans were obtained by alkaline-acid hydrolysis of Pleurotus ostreatus, and the content was characterized by liquid chromatography. To evaluate the effect of β-glucans on the expression of glutathione, Balb/c mice were used, and 4 test groups were established. All groups were fed normally, and the groups treated with acrylamide were administered the compound intragastrically at a concentration of 50 g/mL; β-glucans were administered at a concentration of 50 g/mL. Results: mice exposed to acrylamide showed a marked variation in the activity of glutathione enzymes in the liver. Significant differences (p < 0.05) were only found in the expression of glutathione transferase, which was increased almost 3 times in the group treated with β-glucans as compared with the control group, and 1.5 times as compared with the group treated with acrylamide. Conclusions: the results show that β-glucans could act by increasing the activity of enzymes involved in xenobiotic detoxification, thus protecting the biological system against the harmful effects caused by acrylamide intake.
- Subjects
GLUCANS; PLEUROTUS ostreatus; ACRYLAMIDE; NEUROTOXICOLOGY; LIQUID chromatography; GLUTATHIONE; LIVER enzymes; MUSHROOMS; LIVER; BETA-glucans; BIOTRANSFORMATION (Metabolism); AMIDES; ANIMALS; MICE
- Publication
Nutrición Hospitalaria, 2020, Vol 37, Issue 4, p850
- ISSN
0212-1611
- Publication type
journal article
- DOI
10.20960/nh.03001