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- Title
A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential.
- Authors
Moacă, Elena-Alina; Farcaş, Claudia; Ghiţu, Alexandra; Coricovac, Dorina; Popovici, Ramona; Cărăba-Meiţă, Nela-Loredana; Ardelean, Florina; Antal, Diana Simona; Dehelean, Cristina; Avram, Ştefana
- Abstract
<italic>Melissa officinalis</italic> L. has attracted an increased interest in recent years due to its multiple pharmacological effects. This study aimed to compare two<italic> M. officinalis</italic> ethanolic extracts, obtained from leaves and stems, with regard to their antioxidant activity, total phenolic content, and cytotoxic effects.<italic> M. officinalis</italic> ethanolic extracts showed a very good antioxidant activity in the DPPH test, correlated with the content in total phenols: higher in the case of<italic> M. officinalis</italic> from leaves extract (32.76 mg GAE/g) and lower for<italic> M. officinalis</italic> from stems extract (8.4 mg GAE/g). The lemon balm extracts exerted a cytotoxic effect on breast cancer cells (MDA-MB-231) even at low concentrations (100 <italic>μ</italic>g/mL), whereas, in the case of healthy HaCat cells,<italic> M. officinalis</italic> leaves extract only displayed cytotoxicity at much higher concentrations (500 and 1000 <italic>μ</italic>g/mL) and<italic> M. officinalis</italic> stems extracts were highly cytotoxic (starting at 100 <italic>μ</italic>g/mL). In addition, the extracts exerted inhibitory effects on cell migration and proliferation. These results provide information that confirms the high potential of<italic> M. officinalis</italic> as a source of chemopreventive agents. Moreover, these data can be considered a solid background for further<italic> in vivo</italic> studies involving mice bearing breast tumors.
- Subjects
CELL proliferation; BREAST tumors; CELL death; CELL lines; CELL motility; COMPARATIVE studies; IMMUNOASSAY; LEAVES; PHENOLS; PLANT stems; LEMON balm; PLANT extracts; OXIDATIVE stress
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2018, Vol 2018, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2018/7860456