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- Title
Pathogens infecting the central nervous system.
- Authors
Le Govic, Yohann; Demey, Baptiste; Cassereau, Julien; Bahn, Yong-Sun; Papon, Nicolas
- Abstract
In conclusion, recent advances in ex/in vivo and in vitro BBB and CNS models will not only facilitate understanding of the CNS infection pathophysiology, but also support the screening of novel antimicrobial agents for the treatment of microbial meningitis. Pathogens may access the CNS by crossing the blood-brain barrier (BBB), which normally protects the CNS from microbial invasion, or via transneuronal routes that bypass the BBB. Infections of the central nervous system (CNS) are among the most devastating infectious diseases worldwide and often result in medical emergencies that require prompt management. Toward new therapeutic approaches for treating CNS infections Therapeutic options for CNS infections are highly limited, because the delivery of antimicrobial agents to the affected brain compartments is challenged by the structural complexity and tightness of the human BBB.
- Subjects
NEUROCYSTICERCOSIS; WEST Nile virus; RABIES; CENTRAL nervous system; CENTRAL nervous system infections; LYME disease; PATHOGENIC microorganisms; INFECTION
- Publication
PLoS Pathogens, 2022, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1010234