We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of sevoflurane and desflurane on oxidative stress during general anesthesia for elective cesarean section.
- Authors
Yalcin, Saban; Aydoğan, Harun; Yuce, Hasan Husnu; Kucuk, Ahmet; Karahan, Mahmut Alp; Vural, Mehmet; Camuzcuoğlu, Aysun; Aksoy, Nurten
- Abstract
Background: Anesthetic agents might considerably influence maternal-fetal oxidative stress and antioxidants during cesarean section (CS). The aim of this study was to investigate the effects of desflurane and sevoflurane on oxidative stress parameters both in mothers and newborns undergoing elective CS. Materials and methods: Eighty ASA physical status I-II, term parturients undergoing elective CS under general anesthesia were randomized to desflurane (Group D) and sevoflurane (Group S) groups. Blood samples were collected from mothers before operation and postoperatively and umbilical artery samples were obtained at delivery. Total oxidant status (TOS), total antioxidant capacity (TAC) status, lipid hydroperoxide (LOOH), and free sulfhydryl (-SH) levels were measured and oxidative stress index was calculated. Secondary outcomes included maternal hemodynamics. Results: Preoperative LOOH, TOS, OSI, TAC, and -SH levels were similar among groups. Postoperative maternal serum LOOH, TOS, and OSI levels were significantly increased in Group D compared to Group S ( p = 0.003, p = 0.005, p = 0.04; respectively). Postoperative umbilical artery LOOH, TOS, OSI levels were also significantly increased in Group D compared to Group S ( p = 0.04, p = 0.02, p = 0.01; respectively). Postoperative TOS ( p = 0.001, < 0.001 respectively) and OSI ( p = 0.003, < 0.001 respectively) levels in both Group D and Group S were statistically significantly decreased compared to preoperative levels. Postoperative LOOH and -SH levels in Group S ( p = 0.04, 0.029 respectively) were statistically significantly decreased compared to preoperative levels. There were no significant differences in TAC and -SH levels among groups ( p = nonsignificant [n.s.]). Maternal perioperative mean blood pressure and heart rate were similar among groups ( p = n.s.). Conclusion: Oxidative stress indices might be modified with preferred anesthetic agent and sevoflurane showed more favorable effects than desflurane in view of oxidative stress.
- Subjects
ANESTHETICS; PHARMACODYNAMICS; MATERNAL-fetal exchange; OXIDATIVE stress; ANTIOXIDANTS; CESAREAN section; SEVOFLURANE; HEMODYNAMICS
- Publication
Wiener Klinische Wochenschrift, 2013, Vol 125, Issue 15/16, p467
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-013-0397-0