We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Secretion of human tau fragments resembling CSF-tau in Alzheimer’s disease is modulated by the presence of the exon 2 insert
- Authors
Kim, WonHee; Lee, Sangmook; Hall, Garth F.
- Abstract
Abstract: Abnormal tau cleavage is prominent in the neurofibrillary degeneration characteristic of Alzheimer’s disease (AD) and related tauopathies. We recently showed that cleaved human tau is secreted by specific mechanisms when overexpressed. Here we examined the effect of expressing N-terminal and full length tau constructs in transiently and stably transfected neuronal lines. We show that secreted tau exhibits a cleavage pattern similar to CSF-tau from human AD patients and that tau secretion is specifically inhibited by the presence of the exon 2 insert. These results suggest that tau secretion may play a hitherto unsuspected role in AD and related tauopathies.
- Subjects
ALZHEIMER'S disease; NEURODEGENERATION; CEREBROSPINAL fluid; TETRACYCLINE; ECDYSONE; PROTEOLYSIS; EXONS (Genetics); GENE expression
- Publication
FEBS Letters, 2010, Vol 584, Issue 14, p3085
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2010.05.042