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- Title
The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity.
- Authors
Kempf, Anissa; Tews, Bjoern; Arzt, Michael E.; Weinmann, Oliver; Obermair, Franz J.; Pernet, Vincent; Zagrebelsky, Marta; Delekate, Andrea; Iobbi, Cristina; Zemmar, Ajmal; Ristic, Zorica; Gullo, Miriam; Spies, Peter; Dodd, Dana; Gygax, Daniel; Korte, Martin; Schwab, Martin E.
- Abstract
This study identifies a GPCR, S1PR2, as a receptor for the Nogo-A-Δ20 domain of the membrane protein Nogo-A, which inhibits neuronal growth and synaptic plasticity.
- Subjects
G protein coupled receptors; NOGO receptors; SPHINGOLIPIDS; CENTRAL nervous system diseases; MEMBRANE proteins
- Publication
PLoS Biology, 2014, Vol 12, Issue 1, p1
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.1001763