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- Title
ERK-1/2 activity is required for efficient RSV infection
- Authors
Kong, Xiaoyuan; San Juan, Homero; Behera, Aruna; Peeples, Mark E.; Wu, Jerry; Lockey, Richard F.; Mohapatra, Shyam S.
- Abstract
Respiratory syncytial virus (RSV) infection up-regulates the expression of genes encoding proinflammatory mediators in bronchial epithelial cells. However, the specific signaling events immediately following RSV exposure are poorly understood. Herein, we report that RSV attachment to A549 cells activates both ERK-1 and ERK-2 pathways within 5 min. Inhibition of ERK pathways significantly decreases RSV infection of these cells compared to controls. These results demonstrate that the activation of the ERK-1/2 is required in RSV-induced early gene expression.
- Subjects
RESPIRATORY syncytial virus; EPITHELIAL cells; EXONS (Genetics); GENE expression
- Publication
FEBS Letters, 2004, Vol 559, Issue 1-3, p33
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(04)00002-X