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- Title
Fibronectin is a hypoxia-independent target of the tumor suppressor VHL
- Authors
Bluyssen, Hans A.R.; Lolkema, Martijn P.J.K.; van Beest, Moniek; Boone, Michelle; Snijckers, Cristel M.J.T.; Los, Maartje; Gebbink, Martijn F.B.G.; Braam, Branko; Holstege, Frank C.P.; Giles, Rachel H.; Voest, Emile E.
- Abstract
The von Hippel–Lindau (VHL) tumor suppressor gene regulates the extracellular matrix by controlling fibronectin deposition. To identify novel VHL target genes, we subjected mRNA from VHL-deficient RCC cells (786-0-pRC) and a transfectant re-expressing wildtype VHL (786-0-VHL) to differential expression profiling. Among the differentially expressed genes, we detected that fibronectin is upregulated in the presence of VHL, while it is not affected by hypoxia. Thus regulation of fibronectin deposition by VHL occurs at the transcriptional level, irrespective of oxygen levels.
- Subjects
TUMOR suppressor genes; HYPOXEMIA; GENE targeting; MESSENGER RNA
- Publication
FEBS Letters, 2004, Vol 556, Issue 1-3, p137
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)01392-9