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- Title
The N-terminal domain of SV40 large T antigen represses the HER2/neu-mediated transformation and metastatic potential in breast cancers
- Authors
Chuang, Tzu-Chao; Yu, Yuh-Hua; Lin, Yen-Shing; Wang, Shan-Shue; Kao, Ming-Ching
- Abstract
HER2/neu is known to be overexpressed in approximately 40% of human breast and ovarian cancers and it is associated with increased metastasis and poor prognosis. We have shown previously that the N-terminal domain of simian virus 40 large T antigen (LT425) can act as a transforming suppressor of the HER2/neu oncogene in human ovarian cancer. In the present study, we demonstrate that LT425 can also repress the transforming properties of HER2/neu-overexpressing human breast cancer cells. In addition, the results of a chemotaxis assay and an in vitro chemoinvasion assay further suggest that LT425 can also suppress the metastatic potential of the HER2/neu-transformed breast cancer cells. Taken together, these data clearly suggest that the inhibition of the expression of p185HER2/neu tyrosine kinase by LT425 is capable of suppressing the HER2/neu-mediated transformation and metastatic potential in breast cancers.
- Subjects
SIMIAN viruses; METASTASIS
- Publication
FEBS Letters, 2002, Vol 511, Issue 1-3, p46
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(01)03277-X