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- Title
An Efficient Protocol for the Synthesis of Pyrido[2,3‐d]pyrimidines in Glycerol–Water Medium: Assessment by Green Chemistry Metrics.
- Authors
Jamale, Dattatraya K.; Gurame, Vashishtha M.; Valekar, Navanath J.; Hangirgekar, Shankar P.; Kolekar, Govind B.; Anbhule, Prashant V.
- Abstract
A clean and ecofriendly approach for the catalyst‐free synthesis of pyrido[2,3‐d]pyrimidine derivatives by one‐pot three‐component condensation of aromatic aldehyde, malononitrile and 6‐aminouracil or 6‐amino‐1,3‐dimethyluracil using glycerol–water (3:1) as green reaction media has been developed. Catalyst‐free synthesis with high to excellent yields and use of glycerol–water system as an environmentally benign reaction condition are the prominent features of this strategy. Moreover, excellent outcomes from the calculations of green chemistry metrics reveal the greenness of the protocol.
- Subjects
SUSTAINABLE chemistry; AROMATIC aldehydes; PYRIMIDINE derivatives; CONDENSATION; PRESS
- Publication
Macromolecular Symposia, 2019, Vol 387, Issue 1, pN.PAG
- ISSN
1022-1360
- Publication type
Article
- DOI
10.1002/masy.201800202