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- Title
Transition Metal-Free Approach to Propynenitriles and 3-Chloropropenenitriles.
- Authors
Sharma, Pawan K.; Ram, Sita; Chandak, Navneet
- Abstract
A transition metal-free, facile and efficient one-pot protocol for the synthesis of propynenitriles from readily available 3-chloropropenals is disclosed. The reaction conditions have also been optimized for the exclusive formation and isolation of 3-chloropropenenitriles which are important building blocks in general and are intermediates in the synthesis of propynenitriles. The hallmark of the methodology is the use of non-toxic reagents, milder, metal-free and economically benign reaction conditions avoiding a harsh dehydration step while achieving excellent yields.
- Subjects
NITRILE synthesis; TRANSITION metal compounds; HETEROCYCLIC compounds synthesis; DEHYDRATION reactions; CHEMICAL reagents
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 6, p894
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201501103