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- Title
Effect of quaternized chitosan magnetic nanoparticles carrying indocyanine green phototherapy on cervical cancer cells.
- Authors
Tang, Xiaohui; Zhang, Qian; Aikelamu, Kadireya; Bai, Jingya; Ma, Rong; Wang, Mei; Liu, Chao
- Abstract
The objective of the study is to prepare quaternized chitosan magnetic nanoparticles (ICG@Fe3O4@QCS) loaded with indocyanine green and to investigate their properties. Fe3O4@QCS nanoparticles were prepared by a one-part precipitation method and evaluated for their structure, particle size, morphology, and magnetic responsiveness. ICG@Fe3O4@QCS nanoparticles were prepared by electrostatic adsorption to investigate the properties of ICG@Fe3O4@QCS nanoparticles, such as particle size, zeta potential, encapsulation rate, drug loading, stability, photo- and thermo-conversion efficiencies, degree of release, biosafety, and in vitro antitumor property. Fe3O4@QCS nanoparticles were successfully prepared in the form of short rods with particle sizes around 20–30 nm, positively charged, with basic Fe3O4 skeleton, and possessing specific magnetic responsiveness. ICG@Fe3O4@QCS nanoparticles were successfully prepared, particle size is around 100–150 nm, charged positively, the encapsulation rate is ≥ 90%, the drug loading is 0.05–2.00%, the release is slower compared with the ICG solution, and hemolysis rate is less than 2% in all cases; in the laser irradiation, the nanoparticles can produce ROS and thermal effects and have the function of NIR imaging. Antitumor experiments in vitro showed that ICG@Fe3O4@QCS nanoparticles had strong phototoxicity, had a particular killing effect on tumor cells, and could promote Hela cell apoptosis. ICG@Fe3O4@QCS nanoparticles can be successfully prepared by the electrostatic adsorption method, with the stable nature of ICG@Fe3O4@QCS nanoparticles, which can improve the bioavailability of ICG, and the prepared nanoparticles have good antitumor properties.
- Subjects
MAGNETIC nanoparticles; INDOCYANINE green; CERVICAL cancer; CANCER cells; PRECIPITATION (Chemistry); LIPOSOMES
- Publication
Journal of Nanoparticle Research, 2024, Vol 26, Issue 5, p1
- ISSN
1388-0764
- Publication type
Article
- DOI
10.1007/s11051-024-06003-5