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- Title
A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay.
- Authors
Hokama, Noboru; Shirakura, Takashi; Sunagawa, Sumito; Morishima, Satoko; Nakachi, Sawako; Nishi, Yukiko; Murayama, Yuko; Matsui, Chieko; Hase, Naoki; Tamura, Mizuho; Okamoto, Shiki; Shimabukuro, Michio; Nakamura, Katsunori; Masuzaki, Hiroaki
- Abstract
Among the patients studied, in-depth assessments were performed for 10 patients whose plasma XO activity and clinical parameters were measured consecutively at least five times during the study period. Plasma XO activities in humans are considerably low as compared with those in rodents.[7] Therefore, the sensitivity of the measurement is critical to precisely evaluate the value of XO activity. However, the measurement methods of previous reports have shown difficulties in the detectable range.[[8]] To overcome this issue, in the present study, we measured XO activities using considerably high sensitive fluorometric assay, thereby precisely estimating the plasma XO activities in all samples studied.
- Subjects
XANTHINE oxidase; HEMATOLOGIC malignancies; FAMILIAL hypercholesterolemia
- Publication
Hematological Oncology, 2019, Vol 37, Issue 4, p527
- ISSN
0278-0232
- Publication type
clinical trial
- DOI
10.1002/hon.2659