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- Title
Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model.
- Authors
Duval, Caroline; Leblanc, Alix F.; Aggerbeck, Martine; Coumoul, Xavier; Barouki, Robert; Teixeira-Clerc, Fatima; Lotersztajn, Sophie; Touch, Sothea; Guerre-Millo, Michèle; Emond, Claude
- Abstract
BACKGROUND: Exposure to persistent organic pollutants (POPs) has been associated with the progression of chronic liver diseases, yet the contribution of POPs to the development of fibrosis in non-alcoholic fatty liver disease (NAFLD), a condition closely linked to obesity, remains poorly documented.
- Subjects
LIPID metabolism; LIVER analysis; CARBOHYDRATE analysis; RNA analysis; FATTY acid analysis; ANALYSIS of triglycerides; AMINOTRANSFERASES; ANIMAL experimentation; BIOLOGICAL models; DIET; DIOXINS; FATTY liver; FAT content of food; GENE expression; INFLAMMATION; LIVER diseases; MICE; OBESITY; POLYMERASE chain reaction; PROBABILITY theory; RESEARCH funding; DISEASE exacerbation; FIBROSIS; DISEASE progression; DATA analysis software; DESCRIPTIVE statistics; KRUSKAL-Wallis Test; DISEASE risk factors
- Publication
Environmental Health Perspectives, 2017, Vol 125, Issue 3, p428
- ISSN
0091-6765
- Publication type
Article
- DOI
10.1289/EHP316